Why Can Trigger Finger Improve with PDRN Injections?

by Son’s Rehabilitation Medicine & Chiropractic Clinic in Seoul

Trigger finger is a common condition where a finger gets stuck in a bent position and then suddenly snaps straight — like pulling and releasing a trigger. This happens due to inflammation and thickening of the flexor tendon sheath, especially at the A1 pulley, which prevents smooth tendon movement.

Many patients seek relief through conservative treatments, and one emerging option is PDRN (Polydeoxyribonucleotide) injection therapy. Let’s explore how this treatment may help patients with trigger finger.

🔬 What is PDRN?

PDRN is a DNA-derived compound extracted from salmon sperm cells. It has tissue regeneration and anti-inflammatory properties and works by stimulating the A2A adenosine receptors in our cells. These receptors are involved in healing and inflammation control.

✅ How PDRN May Help in Trigger Finger

1. Reduces Inflammation

PDRN suppresses inflammatory cytokines such as TNF-α and IL-6, which are elevated in chronic tendon inflammation.
👉 This can lead to reduced swelling and pain around the A1 pulley, improving tendon gliding.

  • Reference: Kim et al., International Journal of Molecular Sciences, 2019 — “Anti-inflammatory effects of PDRN in models of arthritis and tendonitis.”

2. Promotes Tissue Repair

PDRN activates fibroblasts and promotes angiogenesis (new blood vessel formation) in injured tissue.
👉 It supports the regeneration of the tendon sheath and surrounding tissues, helping to restore normal movement.

  • Reference: Rho et al., Tissue Engineering Part A, 2015 — “PDRN stimulates tendon healing through fibroblast activation and angiogenesis.”

3. Lower Risk of Side Effects

Compared to steroid injections, PDRN has a lower risk of complications such as skin atrophy or tendon rupture.
👉 It may be a safer option for patients requiring repeated treatment or for those who cannot receive steroids.

⚠️ Important Consideration

While PDRN therapy shows promising effects in clinical practice and research, it is not a cure-all. Some patients may require additional treatments such as physical therapy, splinting, or even surgery depending on the severity. A personalized treatment plan should always be discussed with your physician.

🏥 At Son Cheolho Rehabilitation Medicine & Chiropractic Clinic

We offer individualized treatment plans for patients with trigger finger, combining experience in regenerative medicine and musculoskeletal care. If you're experiencing finger stiffness or locking, you're welcome to visit for a thorough evaluation.

👍Consultation and Appointment Information

Son PMR & Chiropractic Clinic( 2nd floor, 229-1 Gucheonmyun-Ro, Gangdongu, Seoul, South Korea) 

by  Dr Son MD & DC 
Contact: 02-482-8875 in Seoul( +82-2-482-8875)

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