Why PDRN Therapy May Help Patients with Chronic, Treatment-Resistant Low Back Pain

by Son’s Rehabilitation Medicine & Chiropractic Clinic in Seoul

Many patients with chronic low back pain (CLBP) struggle with persistent discomfort even after receiving standard treatments such as injections, medications, physical therapy, or manual therapies. Especially when structural abnormalities are minimal or absent, these cases can be categorized as treatment-resistant or intractable low back pain.

An emerging treatment showing promising results in such patients is PDRN (Polydeoxyribonucleotide) therapy, a regenerative injectable derived from salmon DNA. Originally used in dermatology and wound healing, PDRN is now gaining attention in the field of musculoskeletal rehabilitation.

🔬 What Is PDRN?

PDRN is a DNA fragment extracted from salmon sperm that promotes tissue regeneration, anti-inflammatory effects, and angiogenesis (new blood vessel formation). It binds to A2A adenosine receptors, playing a critical role in controlling inflammation and promoting healing.

✅ Why It May Help Chronic Low Back Pain

1. Anti-inflammatory Mechanism

PDRN activates adenosine A2A receptors, reducing pro-inflammatory cytokines like IL-6 and TNF-α.
This downregulation helps calm chronic inflammation in soft tissues, one of the hidden causes of long-standing pain.

  • Scientific Reference:
    Lim et al., The Spine Journal (2015):

    “Epidural PDRN injection improved mechanical allodynia and motor function in a rat model of spinal stenosis.”

2. Tissue Repair and Soft Tissue Recovery

PDRN promotes fibroblast activation, collagen synthesis, and vascular remodeling, accelerating the repair of damaged ligaments, fascia, and connective tissues.

  • Scientific Reference:
    Korean J Pain (2020):

    “PDRN improves tissue repair by reducing inflammation and inducing cellular regeneration.”
    DOI: 10.3344/kjp.2020.33.4.302

3. Clinical Case Reports Show Symptomatic Relief

In one case study, a patient with sciatica caused by a perineural cyst experienced complete pain relief after three selective PDRN injections.
This suggests the therapy’s potential in radicular pain and degenerative spine-related symptoms.

  • Scientific Reference:
    Lee JH et al., Medicine (Baltimore) (2022):

    “Selective transforaminal PDRN injection relieved sciatica from a perineural cyst.”

4. Excellent Safety Profile

Unlike corticosteroids, PDRN has no known systemic immunosuppressive effect.
Toxicology studies and post-marketing surveillance have shown very low adverse event rates, making it a good option even for elderly patients or those with chronic diseases.

  • Scientific Reference:
    Lee SR et al., Journal of Tissue Engineering and Regenerative Medicine (2016):

    “No systemic toxicity was observed even after long-term administration of PDRN.”
    PMID: 26686874

💡 Summary

PDRN therapy offers a regenerative and anti-inflammatory approach for chronic low back pain that has not responded to conventional treatment. With a strong safety profile and biological plausibility, it may serve as a valuable non-surgical option for select patients.

At  Son Rehabilitation & Chiropractic Clinic, we consider PDRN therapy for patients who have not experienced sufficient relief with other methods. All treatments are personalized and based on thorough clinical evaluation.

Disclaimer: This content is intended for educational purposes only and does not substitute for medical advice. Treatment outcomes may vary by individual condition.

👍Consultation and Appointment Information

Son PMR & Chiropractic Clinic( 2nd floor, 229-1 Gucheonmyun-Ro, Gangdongu, Seoul, South Korea) 

by  Dr Son MD & DC 
Contact: 02-482-8875 in Seoul( +82-2-482-8875)

chson@daum.net

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