PDRN Injections for Joint and Tendon Pain Management

by Son’s Rehabilitation Medicine & Chiropractic Clinic in Seoul

What is PDRN?

PDRN (Polydeoxyribonucleotide) is a compound derived from purified DNA fragments, originally extracted from salmon. It has been studied for its potential to support the body’s natural healing process, and is increasingly used as an adjunctive treatment in musculoskeletal conditions such as joint pain, tendon problems, and shoulder injuries.

How Does It Work?

Research suggests that PDRN may work through several mechanisms:

  1. Anti-inflammatory effects

    • It may reduce pro-inflammatory substances while increasing anti-inflammatory mediators, helping to calm swelling and discomfort in affected tissues.

  2. Tissue repair and regeneration

    • By stimulating cell activity and collagen production, PDRN may encourage the repair of tendons, ligaments, and other soft tissues.

  3. Improved local circulation

    • PDRN has been reported to enhance microcirculation, allowing oxygen and nutrients to reach injured tissues more effectively.

When Is It Used?

In clinical practice, PDRN injections have been applied as a supportive option for a range of musculoskeletal complaints, including:

  • Swelling and pain in the knee joint

  • Tendon inflammation, such as tennis elbow

  • Shoulder conditions involving the rotator cuff (e.g., impingement syndrome, partial supraspinatus tears)

  • Chronic tendon or muscle overuse pain

⚠️ These are general examples reported in medical literature. Treatment should always be tailored to each patient’s condition following a proper diagnosis and consultation.

Why Does It Take Time to Notice Results?

Unlike painkillers or corticosteroid injections that may bring immediate symptom relief, PDRN works by supporting the body’s repair processes. This means that its effects often appear gradually.

  • Tissue healing is a slow process

    • Cell regeneration and collagen remodeling usually take weeks, not days.

  • Inflammation balance is restored step by step

    • Rather than suppressing inflammation aggressively, PDRN helps the body re-establish balance, which naturally takes more time.

  • Individual differences

    • Age, lifestyle, severity of the injury, and overall health can all influence how quickly a person experiences improvement.

Key Takeaway

PDRN injections are not a “quick fix,” but rather a supportive therapy that may help reduce inflammation, improve blood flow, and encourage tissue healing over time. For this reason, patients often need to be patient and consistent with treatment to notice benefits.

👉 Always consult with a qualified healthcare professional to determine whether PDRN therapy is appropriate for your specific condition and to explore complementary treatment options.

👍Consultation and Appointment Information

Son PMR & Chiropractic Clinic( 2nd floor, 229-1 Gucheonmyun-Ro, Gangdongu, Seoul, South Korea) 

by  Dr Son MD & DC 
Contact: 02-482-8875 in Seoul( +82-2-482-8875)

chson@daum.net

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