Scientific Evidence: Can PDRN (DNA Injection) Regenerate a Partial Supraspinatus Tear?

by Son’s Rehabilitation Medicine & Chiropractic Clinic in Seoul

Hello, this is Dr Son Rehabilitation Medicine & Chirorpractic Clinic.

When diagnosed with a supraspinatus tear (one of the key rotator cuff tendons), many patients immediately worry about surgery. However, for partial-thickness tears, evidence-based non-surgical regenerative treatments can offer excellent recovery results.

Today, we will explore the medical evidence behind PDRN (Polydeoxyribonucleotide)—commonly known as the "DNA Injection"—and how it facilitates tendon healing.

1. What is PDRN?

PDRN is a proprietary mixture of DNA fragments derived from salmon sperm. Why salmon? Their DNA base composition is highly biocompatible with humans (over 95% similarity), making it exceptionally safe with minimal risk of immune rejection.

2. The Scientific Evidence: How It Regenerates Tendons

Unlike steroid injections that focus on temporarily blocking inflammation, PDRN works at a cellular level through three proven mechanisms:

  • Activation of A2A Receptors: PDRN binds to adenosine A2A receptors, which triggers a cascade of healing. This process significantly increases the proliferation of fibroblasts—the cells responsible for producing collagen, the primary building block of your tendons.

  • The Salvage Pathway: Healing damaged tissue requires a massive amount of energy and DNA synthesis. PDRN provides ready-to-use nucleotides, allowing cells to bypass the energy-intensive "de novo" synthesis and speed up the repair process.

  • Angiogenesis (New Blood Vessel Formation): Tendons naturally have a poor blood supply, which is why they heal slowly. PDRN promotes the secretion of VEGF (Vascular Endothelial Growth Factor), creating new micro-vessels to deliver oxygen and nutrients directly to the tear site.

3. Clinical Efficacy for Supraspinatus Tears

Clinical studies in physical medicine and rehabilitation have shown that patients treated with PDRN for rotator cuff tendinopathy experience:

  • Significant Pain Reduction: Marked improvement in VAS (Visual Analogue Scale) scores compared to simple physical therapy.

  • Improved Functional Mobility: Increased Range of Motion (ROM) and better scores on shoulder disability indices.

  • Long-term Stability: Unlike steroids, which can weaken tendons over time, PDRN strengthens the structural integrity of the tendon tissue.

4. Maximizing Results

To ensure the best outcome for a partial supraspinatus tear, two factors are critical:

  1. Ultrasound-Guided Precision: To be effective, the PDRN must be injected precisely into the torn area of the tendon. Using real-time ultrasound imaging is essential for accuracy.

  2. Combined Rehabilitation: The injection acts as a "catalyst." For the newly regenerated tissue to become strong and functional, it must be supported by customized physical therapy and strengthening exercises.

Conclusion: A Regenerative Path to Recovery

Surgery is not the only answer for a partial supraspinatus tear. With PDRN treatment, we can harness your body’s natural healing power to repair the damage from within.

If you are suffering from persistent shoulder pain, visit Dr Son Rehabilitation Medicine & Chirorpractic Clinic for a precise diagnosis and an evidence-based recovery plan.

👍Consultation and Appointment Information

Son PMR & Chiropractic Clinic( 2nd floor, 229-1 Gucheonmyun-Ro, Gangdongu, Seoul, South Korea) 

by  Dr Son MD & DC 
Contact: 02-482-8875 in Seoul( +82-2-482-8875)

chson@daum.net

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